Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease

摘要: Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone angiography. The traditional factors cholesterol, high density cholesterol (HDL-C), cholesterol/HDL-C ratios, triglycerides, age, cigarette smoking, systolic blood pressure by discriminant analysis, as cholesterol/bilirubin, cholesterol/(HDL-C+bilirubin), low-density (LDL-C)/(HDL-C+bilirubin) ratios. Each these bilirubin-containing ratios found be an independent predictor the factors. When LDL-C/(HDL-C+bilirubin) ratio included predictors, it improved prediction severe CAD from 28.4 35.3% overall correct classification 68.3 71.1%. 75th percentile used cut-point, diagnostic sensitivities obtained cholesterol/(HDL-C+bilirubin) (52.1%) (51.7%) better than those (40.4%) (P=0.033 0.048, respectively). also over LDL-C/HDL-C (43.4%); however, changes not statistically significant (P=0.096). If confirmed other populations, bilirubin may or apolipoproteins improve CAD.