Association between Serum Bilirubin and Estimated Glomerular Filtration Rate among Elderly Persons

摘要: Chronic kidney disease (CKD) is a major public health problem. However, few studies have examined the significance of serum bilirubin as risk factor for development CKD in general Japanese population. The subjects comprised 413 men (mean age: 79±9 years; (range, 60-100 years) and 637 women 81±8 range, 60-106 who visited medical department Seiyo Municipal Nomura Hospital. We relationship between increased renal function that was evaluated by estimated glomerular filtration rate (eGFR) using CKD-EPI equations modified coefficient. Stepwise multiple regression analysis with eGFR objective variable, adjusted factors explanatory variables, showed (β = 0.11, P<0.001) significantly independently associated eGFR, addition to gender, age, prevalence antihypertensive medication, triglycerides, antidiabetic uric acid. Compared stages 1+2 (eGFR ≥60.0 ml/min/1.73 m2), mean multivariate-adjusted odds ratio {95% (confidence interval (CI)} hypobilirubinemia (first quartile, <0.52 mg/dL) 3.52 (range: 1.88-6.59). Next, control potential confounding factors, data were further stratified medication (antihypertensive, antidyslipidemic, agents), cardiovascular disease. standardized coefficient significant both groups, there no interaction groups. Our demonstrated an independent positive association genders. Low level would be useful function.