Multimeric bispecific binding molecules specific for CD20 and CD3
作者： Bruce Alan Keyt , Fen Zhang , Beatrice Tien-yi Wang , Ramesh Baliga , Omar Duramad
DOI:
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摘要: This disclosure provides pentameric and hexameric CD20 binding molecules methods of using such to direct complement-mediated, T-cell-mediated, or both complement-mediated T-cell-mediated killing CD20-expressing cells.
lens.org 参考文章(146)
Michelle Haynes Pauling, Li Zhu, Shaobing Hua, Human monoclonal antibodies against human CXCR4 ,(2003)
Mich B. Hein, Andrew C. Hiatt, John H. Fitchen, Epithelial tissue targeting agent ,(1998)
David L. Rimm, Melissa Cregger, Aaron J. Berger, Immunohistochemistry and quantitative analysis of protein expression. Archives of Pathology & Laboratory Medicine. ,vol. 130, pp. 1026- 1030 ,(2006) , 10.1043/1543-2165(2006)130[1026:IAQAOP]2.0.CO;2
David G. Maloney, Antonio J. Grillo-López, Christine A. White, David Bodkin, Russell J. Schilder, James A. Neidhart, Nalini Janakiraman, Kenneth A. Foon, Tina-Marie Liles, Brian K. Dallaire, Ken Wey, Ivor Royston, Thomas Davis, Ronald Levy, IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma Blood. ,vol. 90, pp. 2188- 2195 ,(1997) , 10.1182/BLOOD.V90.6.2188
EL-Rashdy M. Redwan, Saleh M. Matar, Ihab A. Serour, Recombinant human J-chain: fix the protein aggregations and yield maximize. Human antibodies. ,vol. 15, pp. 95- 102 ,(2006) , 10.3233/HAB-2006-15304
J. Yun Tso, Naoya Tsurushita, Antibodies or fusion proteins multimerized via homomultimerizing peptide ,(2014)
William R. Strohl, Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters BioDrugs. ,vol. 29, pp. 215- 239 ,(2015) , 10.1007/S40259-015-0133-6
Carrie Goodreau, Tariq Ghayur, Hua Ying, Philip Bardwell, Chengbin Wu, Tri-variable domain binding proteins and uses thereof ,(2011)
Nelson N. H. Teng, Martin E. Sanders, Marcia M. Bieber, Neelima M. Bhat, Antibody induced cell membrane wounding ,(2005)
Caroline Le Morvan, Catherine Decourt, Michel Cogne, Christophe Sirac, Micael Bardel, Non-human transgenic mammal for the constant region of the class a human immunoglobulin heavy chain and applications therof ,(2004)