Small RNAs in major foodborne pathogens: from novel regulatory activities to future applications.

摘要: Small regulatory RNAs (sRNAs) are involved in post-transcriptional control of important cellular processes and contribute to the success a pathogen. Here, we use studies primarily selected from Salmonella enterica Listeria monocytogenes illustrate current status sRNA biology foodborne pathogens. We discuss how activities sRNAs can be affected by base pairing known as ‘sponge RNAs’, or RNA-binding proteins, such newly discovered chaperone ProQ. Furthermore, highlight recent findings for with roles during infection, some which present multiple copies, designated ‘sibling sRNAs’. Importantly, knowledge on sRNA-mediated regulation exploited biotechnological applications, generating gene knockdowns promote desired traits.