Hepatic toxicity of nonsteroidal anti-inflammatory drugs.

摘要: The hepatic toxicity associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is reviewed. NSAIDs include agents in more than 10 classes compounds, many which are capable producing injury. When used to treat rheumatic disease, effects disease itself may complicate diagnosis NSAID-induced Hepatotoxicity caused by be either intrinsic or idiosyncratic nature and manifested hepatocellular injury, cholestasis, a combination both types Intrinsic hepatotoxins, such as salicylates, produce injury large percentage exposed individuals that often dose related occurs after short, fixed latent period. Idiosyncratic sulindac, unusually susceptible persons, usually variable Injury not related. In most cases prognosis those patients who survive acute phase good. Fatalities rarely result from cholestatic Monitoring serum hepatic-enzyme concentrations recommended for receiving indole, pyrazolone, propionic acid since these have been greatest incidence adverse reactions. Enzyme monitoring advisable high-risk other classes. Enhance vigilance on part clinicians, patients, pharmaceutical manufacturers needed reduce hepatotoxicity NSAIDs.