Dyslipidemia in children with chronic kidney disease.
作者： Jeffrey M. Saland , Christopher B. Pierce , Mark M. Mitsnefes , Joseph T. Flynn , Jens Goebel
DOI: 10.1038/KI.2010.311
关键词:
摘要: Dyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease. Here, we describe the prevalence pattern of dyslipidemia from cross-sectional analysis 391 aged 1–16 years, enrolled in multicenter Chronic Kidney Disease Children (CKiD) study, median glomerular filtration rate (GFR), measured by plasma disappearance iohexol, 43 ml/min per 1.73 m 2 . Multivariate was applied to adjust age, gender, body mass index (BMI), GFR, urinary protein/creatinine ratio. Proteinuria nephrotic range 44 BMI exceeded 95th percentile 57 patients this cohort. Baseline lipid found high hypertriglyceridemia 126, increased non-HDL–C 62, reduced HDL–C 83. Overall, 177 had dyslipidemia, whom 79 combined dyslipidemia. Lower GFR associated higher triglycerides, lower HDL–C, non-HDL–C. Nephrotic-range proteinuria significantly Compared >50,
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