Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens.
作者： L. Clifford McDonald , Shannon Rossiter , Constance Mackinson , Yong Yu Wang , Susan Johnson
DOI: 10.1056/NEJMOA010805
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摘要: Background The combination of the streptogramins quinupristin and dalfopristin was approved in United States late 1999 for treatment vancomycin-resistant Enterococcus faecium infections. Since 1974, another streptogramin, virginiamycin, has been used at subtherapeutic concentrations to promote growth farm animals, including chickens. Methods To determine frequency quinupristin-dalfopristin–resistant E. faecium, we selective medium culture samples from chickens purchased supermarkets Georgia, Maryland, Minnesota, Oregon stool outpatients. Results Between July 1998 June 1999, 407 26 stores four states were cultured, as 334 Quinupristin-dalfopristin–resistant isolated 237 chicken carcasses 3 specimens. resistant isolates had low-level resistance (minimal inhibitory concentration [MIC], 4 μg per milliliter; defined ...
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