Regulation of TNF-α- and Fas-Induced Hepatic Apoptosis by NF-κB
作者： David A. Brenner , Etsuro Hatano , Cynthia Bradham , Robert Schwabe , Yuji Iimuro
DOI: 10.1007/978-4-431-67887-8_4
关键词:
摘要: Tumor necrosis factor (TNF)-α and Fas are two potent hepatotoxic agonists in human diseases animal models. When either TNF-α or ligand (FasL) binds to its respective receptor, it initiates parallel cascades leading apoptosis the induction of antiapoptotic proteins. The transcription NF-κB is a critical mediator antiapoptosis liver vivo cultured hepatocytes. mechanisms by which blocks apoptotic pathway under intense investigation. In hepatocyte, induces at least proteins, inducible nitric oxide synthase (iNOS) Bcl-xL. Understanding regulation hepatocytes may provide insights into development novel therapies for disease.
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