Differential effects of Oroxylum indicum bark extracts: antioxidant, antimicrobial, cytotoxic and apoptotic study

摘要: Stem bark of Oroxylum indicum (L) (SBOI) is used by ethnic communities North East India as health tonic and in treating diseases humans animals. The objective this research was to carry out a detailed investigation including total phenolic flavonoid content, antioxidant, antimicrobial, cytotoxic apoptotic activities different solvent extracts SBOI establish correlation between some parameters. Among petroleum ether (PE), dichloromethane methanol (MeOH) extract SBOI, MeOH contained the highest amount (320.7 ± 34.6 mg Gallic acid equivalent/g extract) (346.6 ± 15.2 mg Quercetin content. In vitro antioxidant activity (IC50 22.7 μg/ml) (p > 0.05) also significant inverse observed (r = 0.886)/flavonoid (r = 0.764) content corresponding DPPH IC50. Only inhibited both bacteria fungi. Although, individual showed cytotoxicity on HeLa cells with characteristic features apoptosis, PE caused maximum 112.3 μg/ml, p < 0.05) (33.2 % sub-G0/G1 population) cells. But, there non-inverse MTT IC50 (r = 0.812, p < 0.05)/flavonoid (r = 0.998, three extracts. TLC analysis unique compounds which may have role apoptosis mediated cytotoxicity. These results called for futher chemical characterisation specific bioactivity.