Metabolic Profiling of Phenolic Acids and Oxidative Stress Markers after Consumption of Lonicera caerulea L. Fruit
作者： Jan Heinrich , Kateřina Valentová , Jan Vacek , Irena Palíková , Martina Zatloukalová
DOI: 10.1021/JF304150B
关键词:
摘要: This study investigated the effect of one-week consumption 165 g/day fresh blue honeysuckle berries (208 mg/day anthocyanins) in 10 healthy volunteers. At end intervention, levels benzoic (median 1782 vs 4156), protocatechuic (709 2417), vanillic (2779 4753), 3-hydroxycinnamic (143 351), p-coumaric (182 271), isoferulic (805 1570), ferulic (1086 2395), and hippuric (194833 398711 μg/mg creatinine) acids by LC/MS were significantly increased urine. Clinical chemistry safety markers not altered. Oxidative stress markers, erythrocyte glutathione peroxidase (0.73 0.88 U/g Hb) catalase (2.5 2.8 μkat/g activities, erythrocyte/plasma thiobarbituric acid reactive substance (522 612/33 38 μmol/g Hb/protein) increased, without change plasma antioxidant status. Nonsignificant changes advanced oxidation protein products oxidized LDL observed. The results provide a solid base for further metabolite e...
acs.org
sci-hub.se 参考文章(25)
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
Angelique Stalmach, Christine A. Edwards, JoLynne D. Wightman, Alan Crozier, Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption Journal of Agricultural and Food Chemistry. ,vol. 59, pp. 9512- 9522 ,(2011) , 10.1021/JF2015039
Catherine Felgines, Stéphanie Krisa, Aurélie Mauray, Catherine Besson, Jean-Louis Lamaison, Augustin Scalbert, Jean-Michel Mérillon, Odile Texier, Radiolabelled cyanidin 3-O-glucoside is poorly absorbed in the mouse. British Journal of Nutrition. ,vol. 103, pp. 1738- 1745 ,(2010) , 10.1017/S0007114510000061
Nathan R. Perron, Julia L. Brumaghim, A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding Cell Biochemistry and Biophysics. ,vol. 53, pp. 75- 100 ,(2009) , 10.1007/S12013-009-9043-X
Irena Palikova, Jitka Vostalova, Adela Zdarilova, Alena Svobodova, Pavel Kosina, Rostislav Vecera, David Stejskal, Jitka Proskova, Jan Hrbac, Petr Bednar, Vitezslav Maier, Drahomira Cernochova, Vilim Simanek, Jitka Ulrichova, Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study. Journal of Agricultural and Food Chemistry. ,vol. 58, pp. 1672- 1678 ,(2010) , 10.1021/JF903710Y
Tarja Nurmi, Jaakko Mursu, Marina Heinonen, Anna Nurmi, Raimo Hiltunen, Sari Voutilainen, Metabolism of Berry Anthocyanins to Phenolic Acids in Humans Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 2274- 2281 ,(2009) , 10.1021/JF8035116
Renáta Myjavcová, Petr Marhol, Vladimír Křen, Vilím Šimánek, Jitka Ulrichová, Irena Palíková, Barbora Papoušková, Karel Lemr, Petr Bednář, Analysis of anthocyanin pigments in Lonicera (Caerulea) extracts using chromatographic fractionation followed by microcolumn liquid chromatography-mass spectrometry. Journal of Chromatography A. ,vol. 1217, pp. 7932- 7941 ,(2010) , 10.1016/J.CHROMA.2010.05.058
Martina Zatloukalová, Vladimír Křen, Radek Gažák, Martin Kubala, Patrick Trouillas, Jitka Ulrichová, Jan Vacek, Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II) Bioelectrochemistry. ,vol. 82, pp. 117- 124 ,(2011) , 10.1016/J.BIOELECHEM.2011.06.005
Ryszard Zadernowski, Marian Naczk, Jarosław Nesterowicz, Phenolic Acid Profiles in Some Small Berries Journal of Agricultural and Food Chemistry. ,vol. 53, pp. 2118- 2124 ,(2005) , 10.1021/JF040411P
Xue-Hai Jin, Kazuhiro Ohgami, Kenji Shiratori, Yukari Suzuki, Yoshikazu Koyama, Kazuhiko Yoshida, Iliyana Ilieva, Tsuneo Tanaka, Kazunori Onoe, Shigeaki Ohno, Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo Experimental Eye Research. ,vol. 82, pp. 860- 867 ,(2006) , 10.1016/J.EXER.2005.10.024