作者: Valma Harjutsalo , Lena Sjöberg , Jaakko Tuomilehto
DOI: 10.1016/S0140-6736(08)60765-5
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摘要: Summary Background Finland has the highest incidence of type 1 diabetes worldwide, reaching 40 per 100 000 people year in 1990s. Our aim was to assess temporal trend since 2000 Finnish children aged younger than 15 years and predict number cases future. Methods Children with newly diagnosed who were listed on National Public Health Institute register, Central Drug Register, Hospital Discharge Register 1980–2005 included a cohort study. We excluded patients 2 occurring secondary other conditions, such as steroid use, Down's syndrome, congenital malformations pancreas. Findings 10 737 children—5816 boys 4921 girls—were before age during 1980–2005. The average age-standardised 42·9 (95% CI 42·6–44·3) this period, increasing from 31·4 1980 64·2 2005. age-specific rates 31·0, 50·5, 50·6 at ages 0–4 years, 5–9 10–14-years, respectively. noted significant non-linear component time (p Interpretation is even faster before. new or 14 will double next onset be (0–4 years). Funding Academy Finland, Sigrid Juselius Foundation, Juvenile Diabetes Research Foundation.