Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study.
作者： Ge-Fei Li , Shiyu Ban , Mengxing Wang , Jilei Zhang , Haifeng Lu
DOI: 10.1371/JOURNAL.PONE.0207448
关键词:
摘要: Background Botulinum toxin type A (BoNT-A) is generally considered safe and widely used to treat a variety of clinical conditions involving muscle hyperactivity for cosmetic purposes. However, the effects BoNT-A poisoning (botulism) on brain function are poorly understood. Methodology/Principal findings Herein, we investigated functions in 9 patients who received illegal injections botulinum 18 matched controls by combining analysis methods regional homogeneity (ReHo) amplitude low-frequency fluctuation (ALFF) based resting-state fMRI. Compared with controls, botulism exhibited significantly reduced ReHo values left posterior lobe cerebellum extending right anterior cerebellum, as well parahippocampal gyrus cerebellum. The also showed weakened ALFF cerebellum. Conclusions/Significance The results indicate that may modulate cerebral activation specific areas, which play roles both adverse mechanism underlying treatment BoNT-A.
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