Botulinum Toxin for Neuropathic Pain: A Review of the Literature
作者： Hyun-Mi Oh , Myung Chung
关键词: Neuropathic pain 、 Bioinformatics 、 Postherpetic neuralgia 、 Trigeminal neuralgia 、 Focal dystonia 、 Complex regional pain syndrome 、 Anesthesia 、 Botulinum toxin 、 Neuralgia 、 Occipital neuralgia 、 Medicine
摘要: Botulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential treatment neuropathic pain grown. Recent opinions on the mechanism behind antinociceptive effects of BoNT suggest that it inhibits release peripheral neurotransmitters inflammatory mediators sensory nerves. There is some evidence showing axonal transport BoNT, but remains controversial. The aim this review to summarize experimental clinical effects, mechanisms, therapeutic applications conditions, including postherpetic neuralgia, complex regional syndrome, trigeminal neuralgia. PubMed OvidSP databases were searched 1966 May 2015. We assessed levels according American Academy Neurology guidelines. studies have suggested injection an effective neuralgia likely efficient post-traumatic could also be diabetic neuropathy. It not proven occipital or syndrome.
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