Quality of long-term survival following irradiation for intracranial tumors in children under the age of two

摘要: Abstract Thirty-eight children aged two and under who received radiotherapy alone or post-operatively for primary intracranial tumors from 1957 to 1974 were retrospectively studied survival rate, late radiation sequelae, quality of survival. There 24 deaths, all attributed the disease its complications. The five, ten, fifteen year absolute rates 50 %, 39 38 % respectively, with posterior fossa faring best. 14 survivors, 6 21 1 2 years, evaluated fore physical, neurologic, endocrinologic, psychologic abnormalities. Eight found have minimal no abnormal neurologic findings, 11 within educable range on formal intelligence testing, 12 had Karnofsky performance scores 70 better. was little clinical evidence severe endocrinologic dysfunction except short stature in three. patients correlated a dose greater than 3600 rad hypothalamic-pituitary region. assigned proposed “Composite Quality Survival Scale”(CQS) graded 5 based upon their overall life evaluation. rated Grade 3 better, three essentially normal most respects. We conclude that data justify continued use treatment very young brain tumors. However, there is obvious need further optimization factors (time, dose, volume) order minimize potential effects central nervous system.