Metabolic syndrome is a risk factor for cancer mortality in the general Japanese population: the Jichi Medical School Cohort Study

摘要: Metabolic syndrome (MetS) and cancer are major public health problems worldwide. The relationship between MetS death is of great interest. We examined the predictive value for mortality in Japan. Study participants included 4495 men 7028 women aged 18–90 years who were registered 1992 1995 as part Jichi Medical School Cohort Study. used a definition modified Japanese population. primary outcome was mortality. Additionally, cancer-type specific examined. Analyses conducted with Cox’s regression models adjusted age, smoking status, alcohol drinking marital educational attainment, physical activity, occupational category, menopausal status (only women). During mean follow-up 18.5 years, 473 297 died from cancer. positively associated (hazard ratio [HR], 1.69; 95% confidence interval [CI] 1.21–2.36), but not (HR, 1.21; CI 0.90–1.62). high risk colorectal 3.48; 1.68–7.22) breast 11.90; 2.25–62.84) deaths women. significant predictor