Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion.

摘要: Curcumin has been reported to have anti-fibrotic effect. However, the mechanism of curcumin for liver fibrosis remains obscure. In presenting study, we aimed investigate whether reduce chemokines secretion by inhibiting kupffer cells (KCs) activation decrease Ly6Chi monocyte infiltration in treatment fibrosis. Liver was induced intraperitoneal carbon tetrachloride (CCl4)-injection mice. Mice group received gavage. Pretreatment with significantly protected mice from inflammation and Compared CCl4 group, showed less intrahepatic monocytes, but no difference other leucocyte subtypes. Moreover, reduced monocytes associated pro-inflammatory pro-fibrogenic cytokines, which line decreased numbers monocytes. Further study found that is able KCs chemokines, explains why can during vitro, discovered prevents polarization macrophages toward M1 reduces secretion, involved ERK1/2 p38 pathways. Taken together, first time, verified These results suggested may be considered a promising candidate prevention