Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction.

摘要: A facile, fast and high efficiency micellar EKC has been explored for the analysis UV detection of p-nitrobenzaldehyde 2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one with a buffer electrolyte 30.0 mM tetraborate 50.0 sodium taurodeoxycholate at pH 9.3. Under optimal conditions, linear range from 7.8x10(-2) to 5.0x10(2) those analytes (r(2) > 0.99) was achieved. The LOD 3.9 microM 7.8 p-nitrobenzaldehyde, respectively (S/N = 3). applicability this new method reactants (p-nitrobenzaldehyde cyclopent-2-enone), catalysts (imidazole or N-methyl imidazole 1-benzyl-imidazole) product (2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one) on offline Baylis-Hillman reaction examined. relationship between time amount studied. Meanwhile, three different kinds were investigated getting desired moderate good products. It found that comparing 1-benzyl-imidazole catalyst, imidazole-catalyzed could produce more products within same time. Furthermore, results indicated rate law second-order reaction. constant is 1.34 (+/-0.01)x10(-3) mol(-1) m(3)/s.