Role of primary and secondary maternal viremia in transplacental guinea pig cytomegalovirus transfer.

摘要: The modulation of the outcome intrauterine guinea pig cytomegalovirus (GPCMV) infection by maternal viremia was investigated in model. Virus assay and situ hybridization were used to study GPCMV blood, placentas, fetuses following inoculation pregnant pigs subcutaneous, intracardiac, or intranasal route. Animals inoculated early gestation evaluated every 7 10 days throughout pregnancy. Although placental fetal infections occurred all groups examined, transfer placentas most efficient mothers subcutaneously. Primary followed virus clearance from blood an episode secondary three examined. Placental animals infected subcutaneously intracardially first detected at time primary viremia, persisted gestation, increased during viremia. In contrast, intranasally demonstrated primarily Fetal with detectable but only 33% that experienced These results suggest is associated infections.