Congenital Cytomegalovirus Infection

摘要: This chapter describes some of the key epidemiologic characteristics human cytomegalovirus (HCMV) maternal-fetal infection, including sources maternal infection and populations with increased rates fetal transmission, provides a limited description immune responses associated protection from transmission disease. The seemingly complex natural history congenital HCMV can be greatly simplified by an understanding component infection. Primary during pregnancy develop as result exposure to infectious virus several sources. Epidemiologic studies have documented that infected children sexual represent two most common modes community acquisition HCMV. consequences intrauterine range mild, clinically inapparent severe, life-threatening multiorgan Progressive hearing loss is almost exclusively infants infections which follow primary obvious method limiting disease caused use effective vaccine. may accomplished active vaccination, has been demonstrated universal rubella immunization. Live, replicating vaccines proposed means doing this, but date no direct evidence provided suggest current live vaccine formulations provide such immunity.