Antiviral antibody responses in mothers and their newborn infants with clinical and subclinical congenital cytomegalovirus infections.

摘要: Human cytomegalovirus (HCMV)-specific antibodies were assayed in cord serum and the respective maternal from two groups of newborn infants with congenital HCMV infection. One group exhibited clinically apparent infection multiple organ system involvement, whereas second had subclinical infections. Levels virus-specific IgG reactive several virus-encoded proteins including those major envelope glycoprotein complex significantly higher delivery than Maternal levels IgM virus-binding antibody lower did infection, suggesting acquisition occurred later gestation These results suggested that deficiencies HCMV-specific response not associated other factors, such as early virus during pregnancy, might contribute to severity intrauterine