Congenital cytomegalovirus infection: on the relation between type and time of maternal infection and infant's symptoms.

摘要: Maternal sera from 45 live-born infants with congenital cytomegalovirus (CMV) infection and 4 cases of legal abortion were analysed for CMV IgG IgM. The investigation included routine work prospective studies unselected infants. purpose was to elucidate the relation between maternal type time signs symptoms offspring at birth follow-up. Serological patterns compatible primary during trimesters I II, but also secondary (in least 1 case), associated infant sequelae or death. Asymptomatic found after in II III infection. Virus could not be isolated some fetuses legally aborted due trimester I. Attempts demonstrate IgM activity as a marker active early pregnancy (period abortion) successful only half 10 Symptoms prognostically serious, further course sometimes uneventful even neonatal cerebral A few children without initial developed (impairment hearing).