Adhesion molecules in hematopoietic cells.

摘要: Interaction with stromal cells is known to be crucial for growth and differentiation of hematopoietic cells. To characterize adhesion molecules involved in this interaction, we examined a panel lymphoid, myeloid, mast cell lines We found that very late antigen-4 (VLA-4) vascular molecule 1 (VCAM-1) were major lymphoid myeloid cells, whereas myeloma adhered through hyaluronate. investigated regulation VLA-4 during using neutrophil precursor line, L-G3. Differentiation neutrophils induced by granulocyte colony-stimulating factor was accompanied down-regulation VLA-4. Induced L-G3 proportion the expression Mast used two mechanisms adhere fibroblasts They fibronectin VLA-5 when stimulated steel also directly membrane-anchored c-kit.