Decisional impairments in cocaine addiction, reward bias, and cortical oscillation "unbalance".

摘要: A vast amount of research has suggested that subjects with substance use disorder (SUD) might have difficulty making advantageous decisions opt in favor a longer-term, larger reward than an immediate, smaller reward. The current explored the impact bias and cortical frontal asymmetry (left lateralization effect) SUD response to decisional task (Iowa Gambling Task). Fifty participants 40 controls (CG) were tested using Iowa Task. Electrophysiology (electroencephalography) recording was performed during execution. We measured left right dorsolateral prefrontal cortex power activity. Behavioral responses (gain/loss options); frequency band modulation (asymmetry index) for delta, theta, alpha, beta band; source localization (standardized low-resolution brain electromagnetic tomography) considered. group opted immediate option (loss) more frequently long-term (gain) when compared CG. Secondly, showed increased left-hemisphere activation losing (with reward) choices comparison hemispheric unbalance effect “reward bias” adduced explain impairment SUD.