Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A2A receptor agonist

摘要: Abstract Hearing loss and cognitive decline are commonly associated with aging morbidity. Present clinical interest lies in whether peripheral hearing promotes if prophylaxis selective adenosine receptor agonist CGS21680 effectively mitigates the adverse effects. In current study, male Sprague Dawley rats weighing 200–250 g m were randomly allocated into three groups: Group 1) exposed to 100 dB SPL white noise, 2 h a day for 15 consecutive days, 2) supplemented an agonist, at 100 μg/kg/day prior noise exposure 3) unexposed control rats. Baseline cognition assessed by auditory brainstem response (ABR) water maze respectively was undertaken all groups. Phalloidin stain synaptic ribbons count cochlea, and, Ki67, DCX NeuN hippocampus observed immunohistochemistry. It inferred that showed elevated thresholds of ABR poorer performances spatial working memory when compared controls. On contrary, administered group exhibited improved functions shorter mean latency path-length reach platform, significant reduction induced increased number Ki67 doublecortin (DCX) positive cells their counterparts. Pharmacologic intervention A2A provided adequate protection from maintaining threshold levels, cell viability cochlea & functional/intact reference memory.