Predictive role of GSTs on the prognosis of breast cancer patients with neoadjuvant chemotherapy.
作者： Yun-Lu Bai , Bing Zhou , Xiao-Yue Jing , Bin Zhang , Xiao-Qing Huo
DOI: 10.7314/APJCP.2012.13.10.5019
关键词:
摘要: Objective: To evaluate the predictive value of GST gene polymorphisms with regard to prognosis breast cancer patients receiving neoadjuvant chemotherapy. Methods: A total 159 were included in our study between January 2005 and 2007. All followed up until 2012. Genotyping was based upon duplex polymerase-chain-reaction PCR-CTPP method. Results: Patients null GSTM1 GSTP1 Val/Val genotypes had significantly better response rates chemotherapy when compared non-null Ile/ Ile (OR=1.96 OR=2.14, respectively). genotype a longer average survival time lower risk death than did those (HR=0.66). Similarly, carrying 0.54fold (HR=0.54). Conclusion: significant association found clinical outcomes cases.
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