Glutathione-s-transferase-pi expression in early breast cancer: association with outcome and response to chemotherapy.
作者： Banu K. Arun , Laura A. Granville , Guosheng Yin , Lavinia P. Middleton , Shaheenah Dawood
DOI: 10.3109/07357900903286925
关键词:
摘要: Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement chemotherapy sensitivity and prognosis not well understood. We evaluated the expression of GSTpi predictive role response. Breast tumor samples from 166 patients at stage I/II disease were immunostained for GST-pi, was 96 %. There trend toward improved disease-free survival with high GST-pi (p =.09). statistically non-significant association between outcome adjuvant =.055). Further studies should evaluate relation to response different chemotherapies.
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