Antiviral drug discovery for the treatment of enterovirus 71 infections
作者： Luqing Shang , Mengying Xu , Zheng Yin
DOI: 10.1016/J.ANTIVIRAL.2012.12.005
关键词:
摘要: Enterovirus 71 (EV71) is a small, positive-sense, single-stranded RNA virus in the genus Enterovirus, family Picornavirus. It causes hand, foot and mouth disease infants children, which small percentage of cases progresses to central nervous system infection, ranging from aseptic meningitis fatal encephalitis. Sporadic EV71 infection occur throughout world, but large epidemics have occurred recently Southeast Asia China. There are currently no approved vaccines or antiviral therapies for prevention treatment infection. This paper reviews efforts develop against EV71.
sci-hub.se 参考文章(148)
J. F. Bazan, R. J. Fletterick, Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 7872- 7876 ,(1988) , 10.1073/PNAS.85.21.7872
J. Wang, T. Fan, X. Yao, Z. Wu, L. Guo, X. Lei, J. Wang, M. Wang, Q. Jin, S. Cui, Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues Journal of Virology. ,vol. 85, pp. 10021- 10030 ,(2011) , 10.1128/JVI.05107-11
Betsy Yang, Hau Chuang, Kuender D Yang, Sialylated glycans as receptor and inhibitor of enterovirus 71 infection to DLD-1 intestinal cells Virology Journal. ,vol. 6, pp. 141- 141 ,(2009) , 10.1186/1743-422X-6-141
Shiqi Xie, Kai Wang, Wenjing Yu, Wei Lu, Ke Xu, Jianwei Wang, Bin Ye, Wolfgang Schwarz, Qi Jin, Bing Sun, DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71. Cell Research. ,vol. 21, pp. 1271- 1275 ,(2011) , 10.1038/CR.2011.112
N. Falah, R. Montserret, V. Lelogeais, I. Schuffenecker, B. Lina, J.-C. Cortay, S. Violot, Blocking human enterovirus 71 replication by targeting viral 2A protease Journal of Antimicrobial Chemotherapy. ,vol. 67, pp. 2865- 2869 ,(2012) , 10.1093/JAC/DKS304
Wolfgang Sommergruber, Manfred Zorn, Dieter Blaas, Friederike Fessl, Peter Volkmann, Ingrid Maurer-Fogy, Peter Pallai, Vincent Merluzzi, Martha Matteo, Tim Skern, Ernst Kuechler, Polypeptide 2A of human rhinovirus type 2: Identification as a protease and characterization by mutational analysis Virology. ,vol. 169, pp. 68- 77 ,(1989) , 10.1016/0042-6822(89)90042-1
Wen-Fang Tang, Shing-Ying Yang, Bin-Wen Wu, Jia-Rong Jheng, Yin-Li Chen, Chung-Hsuan Shih, Kwang-Huei Lin, Hsin-Chi Lai, Petrus Tang, Jim-Tong Horng, None, Reticulon 3 Binds the 2C Protein of Enterovirus 71 and Is Required for Viral Replication Journal of Biological Chemistry. ,vol. 282, pp. 5888- 5898 ,(2007) , 10.1074/JBC.M611145200
J. Lu, L. Yi, J. Zhao, J. Yu, Y. Chen, M. C. Lin, H.-F. Kung, M.-L. He, Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1 Journal of Virology. ,vol. 86, pp. 3767- 3776 ,(2012) , 10.1128/JVI.06687-11
Shin-Ru Shih, Shu-Jen Chen, Gholam Hossein Hakimelahi, Hsing-Jang Liu, Chen-Tso Tseng, Kak-Shan Shia, Selective human enterovirus and rhinovirus inhibitors: An overview of capsid-binding and protease-inhibiting molecules. Medicinal Research Reviews. ,vol. 24, pp. 449- 474 ,(2004) , 10.1002/MED.10067
Lalita Ambigai Sivasamugham, Mary Jane Cardosa, Wen Siang Tan, Khatijah Yusoff, Recombinant Newcastle Disease virus capsids displaying enterovirus 71 VP1 fragment induce a strong immune response in rabbits. Journal of Medical Virology. ,vol. 78, pp. 1096- 1104 ,(2006) , 10.1002/JMV.20668