Calcium channel blocker inhibits Western-type diet-evoked atherosclerosis development in ApoE-deficient mice.

摘要: Calcium channel blockers slow the progression of atherosclerosis. The purpose present experiments was to examine action lacidipine in a condition that accelerates development atherosclerosis order test hypothesis protective is unrelated reduction blood pressure. Male ApoE-deficient mice (6 weeks old) were exposed either normal chow (ND) or Western-type diet (WD, adjusted calorie containing 42% from fat) for 8 weeks. induced nitric oxide (NO)-mediated endothelium-dependent relaxation acetylcholine (Max % = 55.8 +/- 2 ND and 46.6 WD, n 8, p < 0.05). Dose-relaxation curves S-nitroso-N-acetylpenicillamine (SNAP) NO donor also significantly rightward-shifted (n 7, ANOVA, 0.01) WD compared with arteries. Chronic treatment (1 3 mg/kg/day) increased acetylcholine-evoked (to 76.6 3.5%, 6, 0.001) prevented loss responsiveness SNAP WD. Plasma renin activity endothelin-1 plasma levels as well thiobarbituric acid-reactive substance kidneys lower treated than untreated ones. In reduced extension atherosclerotic lesions, renal injury increase Experimental data indicate inhibition diet-evoked alterations related both antioxidant vasoactive properties lacidipine.