The 70-kDa peroxisomal membrane protein (PMP70), an ATP-binding cassette transporter.

作者: Tsuneo Imanaka , Kazutoshi Aihara , Yasuyuki Suzuki , Sadaki Yokota , Takashi Osumi

DOI: 10.1385/CBB:32:1-3:131

关键词:

摘要: The 70-kDa peroxisomal membrane protein (PMP70) is one of major components membranes. In rodents, PMP70 markedly induced by administration hypolipidemic agents in parallel with peroxisome proliferation and the induction fatty acid β-oxidation enzymes. an ATP-binding cassette transporter, identified for first time intracellular membranes eukaryotic cells. authors' recent studies suggest that synthesized on free polysomes posttranslationally inserted into membranes, assembles as dimeric or oligomeric forms suggested to be involved metabolic transport long-chain acyl-CoA across

参考文章(32)
C.W. van Roermund, Y. Elgersma, N. Singh, R.J. Wanders, H.F. Tabak, The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. The EMBO Journal. ,vol. 14, pp. 3480- 3486 ,(1995) , 10.1002/J.1460-2075.1995.TB07354.X
P.P. Van Veldhoven, W.W. Just, G.P. Mannaerts, Permeability of the peroxisomal membrane to cofactors of beta-oxidation. Evidence for the presence of a pore-forming protein. Journal of Biological Chemistry. ,vol. 262, pp. 4310- 4318 ,(1987) , 10.1016/S0021-9258(18)61349-3
E. H. Hettema, C. W. van Roermund, B. Distel, M. van den Berg, C. Vilela, C. Rodrigues-Pousada, R. J. Wanders, H. F. Tabak, The ABC transporter proteins Pat1 and Pat2 are required for import of long‐chain fatty acids into peroxisomes of Saccharomyces cerevisiae. The EMBO Journal. ,vol. 15, pp. 3813- 3822 ,(1996) , 10.1002/J.1460-2075.1996.TB00755.X
K Kamijo, S Taketani, S Yokota, T Osumi, T Hashimoto, The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily. Journal of Biological Chemistry. ,vol. 265, pp. 4534- 4540 ,(1990) , 10.1016/S0021-9258(19)39595-X
Yasuyuki SUZUKI, Tadao ORII, Masaki TAKIGUCHI, Masataka MORI, Makoto HIJIKATA, Takashi HASHIMOTO, Biosynthesis of membrane polypeptides of rat liver peroxisomes. Journal of Biochemistry. ,vol. 101, pp. 491- 496 ,(1987) , 10.1093/OXFORDJOURNALS.JBCHEM.A121935
Sakae Shimizu, Tsuneo Imanaka, Tatsuya Takano, Shoji Ohkuma, Major ATPases on clofibrate-induced rat liver peroxisomes are not associated with 70 kDa peroxisomal membrane protein (PMP70). Journal of Biochemistry. ,vol. 112, pp. 733- 736 ,(1992) , 10.1093/OXFORDJOURNALS.JBCHEM.A123967
Jutta Gärtner, Hugo Moser, David Valle, Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome. Nature Genetics. ,vol. 1, pp. 16- 23 ,(1992) , 10.1038/NG0492-16
N. Shani, G. Jimenez-Sanchez, G. Steel, M. Dean, D. Valle, Identification of a Fourth Half ABC Transporter in the Human Peroxisomal Membrane Human Molecular Genetics. ,vol. 6, pp. 1925- 1931 ,(1997) , 10.1093/HMG/6.11.1925
BARBARA C. PATON, SARAH E. HERON, PAUL V. NELSON, C. PHILLIP MORRIS, ALFRED POULOS, Absence of Mutations Raises Doubts about the Role of the 70-kD Peroxisomal Membrane Protein in Zellweger Syndrome American Journal of Human Genetics. ,vol. 60, pp. 1535- 1539 ,(1997) , 10.1016/S0002-9297(07)64247-5
Suresh Subramani, Protein Translocation into Peroxisomes Journal of Biological Chemistry. ,vol. 271, pp. 32483- 32486 ,(1996) , 10.1074/JBC.271.51.32483