Natural Products from Actinobacteria Associated with Fungus-Growing Termites.

摘要: The chemical analysis of insect-associated Actinobacteria has attracted the interest natural product chemists in past years as bacterial-produced metabolites are sought to be crucial for sustaining and protecting insect host. objective our study was evaluate phylogeny bioprospecting associated with fungus-growing termites. We characterized 97 from gut, exoskeleton, fungus garden (comb) termite Macrotermes natalensis used two different bioassays assess their general antimicrobial activity. selected strains investigated culture broth axenic fungus-actinobacterium co-cultures. From these studies, we identified previously-reported PKS-derived barceloneic acid A rubterolones. Analysis yielded a new dichlorinated diketopiperazine derivative tetracyclic lanthipeptides, named rubrominins B. discussed products highlight that highly prolific producers yielding important scaffolds urgently needed future drug development programs.