Association between serotonin transporter promoter polymorphisms and psychological distress in a diabetic population
作者： Kay Wilhelm , Inika Gillis , Jaya Reddy , Phillip B. Mitchell , Lesley Campbell
DOI: 10.1016/J.PSYCHRES.2012.07.008
关键词:
摘要: Investigations into serotonin transporter and anxiety depression have shown an association between stress, onset genotype. We investigated the relationship 5-HTTLPR genotype in a population with diabetes mellitus, condition associated high rates of stress depression. Participants were classified according to 'S' 'L' alleles as well modification single nucleotide polymorphism (SNP) rs25531. The low-expression group (S or L(G) allele carriers) had significantly higher psychological distress (K10) scores (N=234, P=0.047). Subsequent analysis revealed that effect was related symptoms rather than symptoms. Furthermore, main not observed when SNP taken account. Findings suggest 5-HTTLPR/rs25531 is sample subjects diabetes.
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