Human pancreatic secretory trypsin inhibitor : Distribution, actions and possible role in mucosal integrity and repair

摘要: Pancreatic secretory trypsin inhibitor is a potent protease which was originally identified in the pancreas. It has subsequently been shown to be present mucus-secreting cells throughout gastrointestinal tract and also kidney, lung breast. Its major roles are likely prevent premature activation of pancreatic proteases decrease rate mucus digestion by luminal within stomach colon. In addition, PSTI increases proliferation variety cell lines stimulates migration, possibly acting via EGF receptor. These findings suggest that may involved both early late phases healing response following injury. Further studies including production transgenic overexpression knockout models should help elucidate physiological function this peptide.