Influence of inflammation and atrophy on pancreatic secretory trypsin inhibitor levels within the gastric mucosa
作者： Raymond J. Playford , Andrew M. Hanby , Cecily Quinn , John Calam
DOI: 10.1016/0016-5085(94)90709-9
关键词: Stomach 、 Gastric mucosa 、 Internal medicine 、 Foveolar cell 、 Gastroenterology 、 Antrum 、 Gastritis 、 Atrophic gastritis 、 Biology 、 Pathology 、 Proteolytic enzymes 、 PstI
摘要: Abstract Background/Aims: Gastrointestinal epithelia contain a powerful protease inhibitor called pancreatic secretory trypsin (PSTI). Gastric mucus obtained from patients with atrophic gastritis or gastric ulceration shows changes suggestive of excessive proteolytic digestion. Therefore, the aim this study was to examine whether mucosal PSTI levels are affected by and/or ulceration. Methods: Mucosal were measured in 12 normal histology and 26 Results: In control subjects, mean concentrations 990 ng/mg protein (95% confidence interval, 819–1195) antrum 445 395–502) body. Immunostaining for strongly positive pyloric glands foveolar/surface neck cells Tissue reduced 40% biopsy specimens showing superficial ( P = 0.035) 75% Conclusions: The decrease tissue associated atrophy probably represents permanent reduction one defense mechanisms. This may lead maintenance even expansion gastritic process time.
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