Pancreatic metaplasia of the human gastric mucosa is associated with high expression of transforming growth factor α but not of epidermal growth factor
作者： J. STACHURA , J. KONTUREK , K. URBAŇZYK , J. BOGDAL , W. DOMSCHKE
DOI: 10.1111/J.1365-2559.1995.TB00321.X
关键词:
摘要: Pancreatic acinar metaplasia of the gastric mucosa is a newly recognized entity. Its physiological relevance and association with other pathological conditions in stomach remain to be elucidated. We studied by immunohistochemistry expression growth markers biopsies from 15 patients pancreatic metaplasia. (both dispersed forms) was found routine paraffin sections confirmed strong lipase immunoreactivity. In parallel we performed immunostaining for epidermal factor (EGF), transforming factor-α (TGFα) receptor (EGFr) using biotin streptavidin method. Strong TGFα but only weak EGF noted within metaplastic mucosa. EGFr strongly expressed, not areas also surrounding
sci-hub.se 参考文章(12)
Stachura J, Urbańczyk K, Domschke W, Bogdał J, Konturek J, Dispersed and acinar forms of pancreatic metaplasia in human gastric mucosa. Folia Histochemica Et Cytobiologica. ,vol. 32, pp. 251- ,(1994)
Raymond J. Playford, Andrew M. Hanby, Cecily Quinn, John Calam, Influence of inflammation and atrophy on pancreatic secretory trypsin inhibitor levels within the gastric mucosa Gastroenterology. ,vol. 106, pp. 735- 741 ,(1994) , 10.1016/0016-5085(94)90709-9
Peter J. Dempsey, James R. Goldenring, Carol J. Soroka, Irvin M. Modlin, Robert W. McClure, Christopher D. Lind, David A. Ahlquist, Mark R. Pittelkow, David C. Lee, Eric P. Sandgren, David L. Page, Robert J. Coffey, Possible role of transforming growth factor α in the pathogenesis of Ménétrier's disease: Supportive evidence from humans and transgenic mice Gastroenterology. ,vol. 103, pp. 1950- 1963 ,(1992) , 10.1016/0016-5085(92)91455-D
B. Hofstad, M. Vatn, S. Larsen, M. Osnes, Reliability of in situ measurements of colorectal polyps. Scandinavian Journal of Gastroenterology. ,vol. 27, pp. 59- 64 ,(1992) , 10.3109/00365529209011168
Mustapha AOUBALA, Cecile DANIEL, Alain CARO, Margarita G. IVANOVA, Michel HIRN, Louis SARDA, Robert VERGER, Epitope mapping and immunoinactivation of human gastric lipase using five monoclonal antibodies FEBS Journal. ,vol. 211, pp. 99- 104 ,(1993) , 10.1111/J.1432-1033.1993.TB19874.X
Chikao Torikata, Makio Mukai, Hirobumi Kawakita, Ultrastructure of metaplastic ciliated cells in human stomach. Virchows Archiv. ,vol. 414, pp. 113- 119 ,(1989) , 10.1007/BF00718590
A. Tarnawski, S.-Y. Lu, J. Stachura, I. J. Sarfeh, Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptor. Scandinavian Journal of Gastroenterology. ,vol. 193, pp. 59- 63 ,(1992) , 10.3109/00365529209096007
Claudio Doglioni, Licia Laurino, Angelo P. Dei Tos, Michele De Boni, Giuseppe Franzin, Paola Braidotti, Giuseppe Viale, Pancreatic (Acinar) Metaplasia of the Gastric Mucosa: Histology, Ultrastructure, Immunocytochemistry, and Clinicopathologic Correlations of 101 Cases The American Journal of Surgical Pathology. ,vol. 17, pp. 1134- 1143 ,(1993) , 10.1097/00000478-199311000-00006
Piero Tosi, M. Isabel Filipe, Pietro Luzi, Clelia Miracco, Rosa Santopietro, Roberto Lio, Vincenzo Sporza, Paolo Barbini, Gastric intestinal metaplasia type III cases are classified as low-grade dysplasia on the basis of morphometry. The Journal of Pathology. ,vol. 169, pp. 73- 78 ,(1993) , 10.1002/PATH.1711690112
H. Moreau, A. Bernadac, Y. Gargouri, F. Benkouka, R. Laugier, R. Verger, Immunocytolocalization of human gastric lipase in chief cells of the fundic mucosa Histochemistry. ,vol. 91, pp. 419- 423 ,(1989) , 10.1007/BF00493829