Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 After Induction of Ischaemia
作者： C. K. Park , D. G. Nehls , D. I. Graham , G. M. Teasdale , J. McCulloch
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摘要: The effects of the glutamate N-methyl-D-aspartate receptor antagonist MK-801 in reducing ischaemic brain damage have been examined anaesthetised cats, with drug treatment being initiated 2 h after induction cerebral ischaemia. Focal ischaemia was produced by permanent occlusion one middle artery, and animals were killed 6 later. amount early irreversible assessed at 16 predetermined stereotactic planes. Treatment (5 mg/kg, i.v.) artery reduced significantly volume (from 1,625 ± 384 mm3 hemisphere vehicle-treated cats to 792 385 MK-801-treated cats). demonstration MK-801, when agent is administered ischaemia, extends therapeutic potential such agents focal humans.
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