The characterization of isobaric product ions of fentanyl using multi-stage mass spectrometry, high-resolution mass spectrometry and isotopic labeling

摘要: This study uses a combination of multi-stage mass spectrometry (MSn ), accurate measurements - with high-resolution (HRMS) and isotopic labeling to characterize the fragmentation behavior fentanyl 4-ANPP. By understanding its analogs in more detail, toxicologists seized drug analysts will be better poised identify new emerging fentalogs, which are increasingly common deadly adulterants growing opioid crisis. Throughout literature product ion at m/z 188 is often most abundant fragment spectrometric analysis analogs, this used for both qualitative quantitative determinations. Our work shows there least three different structures isobaric ions 188, they each form via pathways. The development mechanisms explain observed pathways main precursor 4-ANPP helps contribute advancement knowledge about could provide important information identification future analogs.