Assoziation eines funktionellen CTGF Promotorpolymorphismus (CCN2c.-945) auf Herzerholung unter mechanischer Kreislaufunterstützung bei Patienten mit idiopathischer dilatativer Kardiomyopathie
作者： Laura Allison Steinhoff
DOI:
关键词:
摘要: ENGLISH 13 ABSTRACT DEUTSCH 14 1. EINLEITUNG 15 1.1. Herzinsuffizienz 1.2. Kardiomyopathien 1.3. Dilatative Kardiomyopathie eine primare Erkrankung des Muskels 17 1.4. Mechanische Herzunterstutzungssysteme 20 1.4.1. Historischer Hintergrund uber die Entwicklung von Herzunterstutzungssystemen (mechanical circulatory support, MCS) 1.4.2. Systeme der Herzunterstutzung (Ventricular assist device, VAD, ...... 1.4.3. Pulsatiler versus kontinuierlicher Flow 22 1.4.4. Therapeutische Ansatze MCS 23 1.4.4.1. „Bridge to transplantation“ und destination“ 25 1.4.4.2. recovery“ 1.5. Molekulare Mechanismen Remodeling Reverse Prozessen 26 1.5.1. bei chronischer 1.5.2. nach 27 1.6. Connective Tissue Growth Factor 29 1.7. Fragestellung 31 2. MATERIALIEN 33 2.1. Gerate 2.2. Chemikalien 34 2.3. Enzyme Nukleotide 2.4. DNA-Molekulargewichtsmarker 35 2.5. Wasser 2.6. Materialien jeweiligen Arbeitsschritte 2.6.1. Primer Design 2.6.2. fur PolymeraseKettenreaktion (PCR) 36 2.6.3. Automatische Sequenzierung 38 2.6.4. RestriktionsFragmentLangenPolymorphismusAnalyse (RFLPAnalyse) 39
参考文章(58)
Sabine Hassfeld, Christian Geier, Andreas Perrot, Karl Josef Osterziel, Familial dilated cardiomyopathy Herz. ,vol. 30, pp. 529- 534 ,(2005) , 10.1007/S00059-005-2732-3
Michael E. DeBakey, Left ventricular bypass pump for cardiac assistance The American Journal of Cardiology. ,vol. 27, pp. 3- 11 ,(1971) , 10.1016/0002-9149(71)90076-2
Simon Stewart, Kate MacIntyre, David J. Hole, Simon Capewell, John J.V. McMurray, More ‘malignant’ than cancer? Five‐year survival following a first admission for heart failure European Journal of Heart Failure. ,vol. 3, pp. 315- 322 ,(2001) , 10.1016/S1388-9842(00)00141-0
Theodore W. Kurtz, M.Anne Spence, Genetics of essential hypertension The American Journal of Medicine. ,vol. 94, pp. 77- 84 ,(1993) , 10.1016/0002-9343(93)90124-8
D. J. Goldstein, Worldwide Experience With the MicroMed DeBakey Ventricular Assist Device® as a Bridge to Transplantation Circulation. ,vol. 108, pp. 272- 277 ,(2003) , 10.1161/01.CIR.0000087387.02218.7E
Norimichi Koitabashi, Masashi Arai, Kazuo Niwano, Atai Watanabe, Michiko Endoh, Masahiko Suguta, Tomoyuki Yokoyama, Hiroshi Tada, Takuji Toyama, Hitoshi Adachi, Shigeto Naito, Shigeru Oshima, Takashi Nishida, Satoshi Kubota, Masaharu Takigawa, Masahiko Kurabayashi, Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure European Journal of Heart Failure. ,vol. 10, pp. 373- 379 ,(2008) , 10.1016/J.EJHEART.2008.02.011
Carmen Fonseca, Gisela E. Lindahl, Markella Ponticos, Piersante Sestini, Elisabetta A. Renzoni, Alan M. Holmes, Paolo Spagnolo, Panagiotis Pantelidis, Patricia Leoni, Neil McHugh, Carmel J. Stock, Xu Shi-Wen, Christopher P. Denton, Carol M. Black, Kenneth I. Welsh, Roland M. du Bois, David J. Abraham, A polymorphism in the CTGF promoter region associated with systemic sclerosis. The New England Journal of Medicine. ,vol. 357, pp. 1210- 1220 ,(2007) , 10.1056/NEJMOA067655
M B Codd, D D Sugrue, B J Gersh, L J Melton, Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation. ,vol. 80, pp. 564- 572 ,(1989) , 10.1161/01.CIR.80.3.564
Markus Grompe, The rapid detection of unknown mutations in nucleic acids Nature Genetics. ,vol. 5, pp. 111- 117 ,(1993) , 10.1038/NG1093-111
J WOHLSCHLAEGER, K SCHMITZ, C SCHMID, K SCHMID, P KEUL, A TAKEDA, S WEIS, B LEVKAU, H BABA, Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes. Cardiovascular Research. ,vol. 68, pp. 376- 386 ,(2005) , 10.1016/J.CARDIORES.2005.06.030