miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation
作者： Hu‑Nian Li , Xu Zhao , Yong‑Jiu Zha , Fang Du , Jie Liu
关键词:
摘要: In the present study, we examined function of microRNA (miR)-146a-5p in patients with refractory Mycoplasma pneumoniae pneumonia. brief, expression miR-146a-5p was reduced Downregulation inflammation an vitro model pneumonia, whilst overexpression promoted inflammation. induced protein ATP-binding cassette subfamily G member 1 (ABCG1) and interleukin receptor-associated kinase (IRAK-1), while suppressed observed aforementioned proteins following The administration small interfering RNA against RXR or IRAK-1 attenuated effects on Collectively, these results suggested that ABCG1 pneumonia via downregulation IRAK-1.
sci-hub.st 参考文章(30)
Sylvia Chen, Lyne Villeneuve, Derek Jonker, Félix Couture, Isabelle Laverdière, Erica Cecchin, Federico Innocenti, Giuseppe Toffoli, Eric Lévesque, Chantal Guillemette, ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients. Pharmacogenetics and Genomics. ,vol. 25, pp. 573- 583 ,(2015) , 10.1097/FPC.0000000000000168
Shereen M. Aleidi, Vicky Howe, Laura J. Sharpe, Alryel Yang, Geetha Rao, Andrew J. Brown, Ingrid C. Gelissen, The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Journal of Biological Chemistry. ,vol. 290, pp. 24604- 24613 ,(2015) , 10.1074/JBC.M115.675579
Xiaomin Fang, Xiao Liu, Cui Meng, Yanfeng Fu, Xuemin Wang, Bixia Li, Feng Tu, Fang Zhao, Shouwen Ren, Breed-linked polymorphisms of porcine toll-like receptor 2 (TLR2) and TLR4 and the primary investigation on their relationship with prevention against Mycoplasma pneumoniae and bacterial LPS challenge Immunogenetics. ,vol. 65, pp. 829- 834 ,(2013) , 10.1007/S00251-013-0727-4
Ke-Wu Zeng, Tai Zhang, Hong Fu, Geng-Xin Liu, Xue-Mei Wang, Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia European Journal of Pharmacology. ,vol. 692, pp. 29- 37 ,(2012) , 10.1016/J.EJPHAR.2012.05.030
Prithiksha Ramkaran, Sajidah Khan, Alisa Phulukdaree, Devapregasan Moodley, Anil A. Chuturgoon, miR-146a Polymorphism Influences Levels of miR-146a, IRAK-1, and TRAF-6 in Young Patients with Coronary Artery Disease Cell Biochemistry and Biophysics. ,vol. 68, pp. 259- 266 ,(2014) , 10.1007/S12013-013-9704-7
Kenneth J. Livak, Thomas D. Schmittgen, ANALYSIS OF RELATIVE GENE EXPRESSION DATA USING REAL-TIME QUANTITATIVE PCR AND THE 2(-DELTA DELTA C(T)) METHOD Methods. ,vol. 25, pp. 402- 408 ,(2001) , 10.1006/METH.2001.1262
Katleen Vranckx, Dominiek Maes, Silvana B Marchioro, Iris Villarreal, Koen Chiers, Frank Pasmans, Freddy Haesebrouck, None, Vaccination reduces macrophage infiltration in bronchus-associated lymphoid tissue in pigs infected with a highly virulent Mycoplasma hyopneumoniae strain BMC Veterinary Research. ,vol. 8, pp. 24- 24 ,(2012) , 10.1186/1746-6148-8-24
L Guo, CH Chen, LL Zhang, XJ Cao, QL Ma, P Deng, G Zhu, CY Gao, BH Li, Y Pi, Y Liu, ZC Hu, L Zhang, ZP Yu, Z Zhou, JC Li, None, IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs. Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2015.212
Thomas J Marrie, Michael Beecroft, Zeljka Herman-Gnjidic, Melanie Poulin-Costello, Symptom resolution in patients with Mycoplasma pneumoniae pneumonia. Canadian Respiratory Journal. ,vol. 11, pp. 573- 577 ,(2004) , 10.1155/2004/659187
Yuanyuan Zhang, Yunlian Zhou, Shuxian Li, Dehua Yang, Xiling Wu, Zhimin Chen, The Clinical Characteristics and Predictors of Refractory Mycoplasma pneumoniae Pneumonia in Children. PLOS ONE. ,vol. 11, ,(2016) , 10.1371/JOURNAL.PONE.0156465