Immune regulation by ubiquitin conjugation.

摘要: It becomes increasingly evident that protein ubiquitination is closely linked to many aspects of the immune system and E3 ubiquitin ligases play an important role in those processes via specific targeting substrates. Gene database searching has indicated there are several hundred ligases, with majority being RING finger-containing ligases. conceivable will be very complicated interplay among Several may target same substrate, or otherwise, one ligase different substrates under diverse physiological conditions. In addition, list de-ubiquiting enzymes involved regulation increase near future. mentioned biochemical molecular approaches still main tools for identification a substrate particular ligase. The relevance such findings correlated genetic investigations. any case, field research on modulation continue hot topic years come.