Severity Score for Predicting In-facility Ebola Treatment Outcome

作者: Jia Bainga Kangbai , Christian Heumann , Michael Hoelscher , Foday Sahr , Guenter Froeschl

DOI: 10.1016/J.ANNEPIDEM.2020.07.017

关键词:

摘要: Abstract Purpose Sierra Leone recorded the highest incidence rate for 2013–2016 West African Ebola outbreak. In this investigation, we used medical records of patients with different sociodemographic and clinical features to determine factors that are associated treatment outcome during outbreak in constructed a predictive in-facility mortality score. Methods We anonymized 1077 laboratory-confirmed pediatric adult EVD who received at 34 Military Hospital Police Training School Treatment Centers between period June 2014 April 2015. later determined case fatality rates Ebola, odds dying treatment, score these based on their characteristics. Results model partitioned study population into three risk groups equal patient numbers, scoring: low (score ≤ –5), medium –4 1), high-risk group ≥ 2). The CFR belonging low- (≤–5), (–4 high- (≥2) were 0.56%, 9.75%, 67.41%, respectively. Conclusions succeeded designing an reflects severity can assist prioritization EVD.

参考文章(34)
Athena P. Kourtis, Kristie Appelgren, Michelle S. Chevalier, Anita McElroy, Ebola Virus Disease: Focus on Children. Pediatric Infectious Disease Journal. ,vol. 34, pp. 893- 897 ,(2015) , 10.1097/INF.0000000000000707
T. Yan, J. Mu, E. Qin, Y. Wang, L. Liu, D. Wu, H. Jia, Z. Li, T. Guo, X. Wang, Y. Qin, Y. Li, S. Chen, Y. Zhang, J. Zhang, Y. Wu, S. Wang, J. Li, Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 34, pp. 2089- 2095 ,(2015) , 10.1007/S10096-015-2457-Z
Marta Lado, Naomi F Walker, Peter Baker, Shamil Haroon, Colin S Brown, Daniel Youkee, Neil Studd, Quaanan Kessete, Rishma Maini, Tom Boyles, Eva Hanciles, Alie Wurie, Thaim B Kamara, Oliver Johnson, Andrew JM Leather, None, Clinical features of patients isolated for suspected Ebola virus disease at Connaught Hospital, Freetown, Sierra Leone: a retrospective cohort study Lancet Infectious Diseases. ,vol. 15, pp. 1024- 1033 ,(2015) , 10.1016/S1473-3099(15)00137-1
Nadia Wauquier, Pierre Becquart, Cindy Padilla, Sylvain Baize, Eric M. Leroy, Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis PLoS Neglected Tropical Diseases. ,vol. 4, pp. e837- ,(2010) , 10.1371/JOURNAL.PNTD.0000837
M. Barry, F.A. Traoré, F.B. Sako, D.O. Kpamy, E.I. Bah, M. Poncin, S. Keita, M. Cisse, A. Touré, Ebola outbreak in Conakry, Guinea: epidemiological, clinical, and outcome features. Medecine Et Maladies Infectieuses. ,vol. 44, pp. 491- 494 ,(2014) , 10.1016/J.MEDMAL.2014.09.009
Anita K. McElroy, Bobbie R. Erickson, Timothy D. Flietstra, Pierre E. Rollin, Stuart T. Nichol, Jonathan S. Towner, Christina F. Spiropoulou, Biomarker correlates of survival in pediatric patients with Ebola virus disease. Emerging Infectious Diseases. ,vol. 20, pp. 1683- 1690 ,(2014) , 10.3201/EID2010.140430
YunFang Zhang, DaPeng Li, Xia Jin, Zhong Huang, Fighting Ebola with ZMapp: spotlight on plant-made antibody Science China Life Sciences. ,vol. 57, pp. 987- 988 ,(2014) , 10.1007/S11427-014-4746-7
Daniel S. Chertow, Christian Kleine, Jeffrey K. Edwards, Roberto Scaini, Ruggero Giuliani, Armand Sprecher, Ebola Virus Disease in West Africa — Clinical Manifestations and Management New England Journal of Medicine. ,vol. 371, pp. 2054- 2057 ,(2014) , 10.1056/NEJMP1413084