Pseudomyxoma peritonei: new concepts in diagnosis, origin, nomenclature, and relationship to mucinous borderline (low malignant potential) tumors of the ovary.

摘要: For many years the clinical syndrome of PMP has been enigmatic. Based on recent studies reevaluating condition, tumors previously designated can now be viewed as two pathologically and prognostically distinct disease processes. Disseminated peritoneal adenomucinosis is characterized by copious mucinous ascites (the classical PMP) histologically bland tumors. The condition attributed to a ruptured appendiceal adenoma in vast majority cases. It an indolent course when surgically treated but may recur over months years. Peritoneal carcinomatosis abundant tumor, similar presentation adenomucinosis. However, microscopically, have architectural cytologic features carcinoma, are derived from gastrointestinal adenocarcinomas, associated with significantly worse prognosis than cases A third group displays intermediate or discordant histologic manifests very pure carcinomatosis. Women often concomitant ovarian that suggest primary neoplasia. Morphologic, immunohistochemical, molecular support interpretation secondary origin women well men. recognition nearly all DPAM seriously calls into question existence borderline Therefore, should classified either benign malignant. Tumors exhibiting currently interpreted included atypical proliferative