Plasminogen activators and plasminogen activator inhibitors in synovial fluid. Difference between inflammatory joint disorders and osteoarthritis

摘要: The plasminogen activator (PA)/plasminogen inhibitor (PAI) system is believed to be involved in connective tissue remodelling joint disease and both PA PAI production has been shown several cell types the joint. We quantified immunoreactive synovial fluid (SF) correlated their levels of cartilage derived proteoglycans, radiologically visible involvement signs local inflammation. PAI-2 concentrations were increased, compared normal plasma levels, patients with rheumatoid arthritis (RA) reactive arthritis, but not osteoarthritis (OA). Thirty percent RA, no patient OA had increased PAI-1. Increased urokinase type (u-PA) found RA OA. Tissue (t-PA) low groups. SF proteoglycan did correlate or PAI. Concentrations significantly leukocyte count cytidine deaminase (CD) activity u-PA CD activity. Both detected supernatants from lysed polymorphonuclear cells. This suggests that addition release cells chondrocytes these components may also released Our results support a pathophysiological role for fibrinolytic disease, possibly more pronounced inflammatory disorders than