The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets.

摘要: A major problem for cancer patients is the metastasis of cells from primary tumor. This involves: (1) migration through basement membrane; (2) dissemination via circulatory system; and (3) invasion into a secondary site. Metastasis suppressors, by definition, inhibit at any step metastatic cascade. Notably, Src non-receptor, cytoplasmic, tyrosine kinase, which becomes aberrantly activated in many cancer-types following stimulation plasma membrane receptors (e.g., receptor kinases integrins). There evidence prominent role tumor progression-related events such as epithelial-mesenchymal transition (EMT) development metastasis. However, precise molecular interactions with suppressors remain unclear. Herein, we review known summarize recent advances understanding mechanisms how these proteins modulation Src. Particular emphasis bestowed on potent suppressor, N-myc downstream regulated gene 1 (NDRG1) its signaling Recent studies demonstrated novel mechanism NDRG1 plays significant regulating cell inhibiting activity. Moreover, discuss rationale targeting suppressor genes sound therapeutic modality, several examples literature where strategies show promise. Collectively, this summarizes essential their effects progression interesting unresolved issues regarding well potential targets are also discussed.