Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold.

摘要: Study Objectives: The effect of common sedatives on upper airway physiology and breathing during sleep in obstructive apnea (OSA) has been minimally studied. Conceptually, certain may worsen OSA some patients. However, could improve with patients a low respiratory arousal threshold. This study aimed to test the hypothesis that trazodone increases threshold Secondary aims were examine effects dilator muscle activity, collapsibility, sleep. Design: Patients studied 4 separate nights according within-subjects cross-over design. Setting: Sleep laboratory. Patients: Seven Interventions: In-laboratory polysomnograms obtained at baseline after 100 mg was administered, followed by detailed overnight experiments under same conditions. During studies, continuous positive pressure transiently lowered measure (negative epiglottic prior arousal), activity (genioglossus tensor palatini), collapsibility (Pcrit). Measurements Results: Trazodone increased 32 ± 6% (-11.5 1.4 versus -15.3 2.2 cmH2O, P < 0.01) but did not alter apnea-hypopnea index (39 12 39 11 events/h sleep, = 0.94). Dilator Pcrit also systematically change trazodone. Conclusions: without major impairment or collapsibility. magnitude insufficient overcome compromised anatomy these