Pyrrole studies. Part 32. A novel ring-cleavage reaction of the pyridazine ring during the reaction of 6H-pyrrolo[3,4-d]pyridazines with dimethyl acetylenedicarboxylate

作者： Teresa Hernandez de la Figuera Gomez , Jos� Sep�lveda Arques , R. Alan Jones , Helen M. Dawes , Michael B. Hursthouse

DOI: 10.1039/P19850000899

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摘要: The reaction of 6H-pyrrolo[3,4-d]pyridazines with dimethyl acetylenedicarboxylate in methanol leads initially to (1,2-dihydro-1-methoxy-6H-pyrrolo[3,4-d]pyridazin-2-yl)fumaric esters, which are unstable the presence water and undergo a ring-cleavage yield 4,5-diaza-6-pyrrol-3-ylhexa-3,5-dienoates. structure 4-formyl-2,5-dimethylpyrrol-3-yl derivative has been confirmed by X-ray crystallography.

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Pyrrole studies. Part 32. A novel ring-cleavage reaction of the pyridazine ring during the reaction of 6H-pyrrolo[3,4-d]pyridazines with dimethyl acetylenedicarboxylate

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Pyrrole studies. Part 32. A novel ring-cleavage reaction of the pyridazine ring during the reaction of 6H-pyrrolo[3,4-d]pyridazines with dimethyl acetylenedicarboxylate

来源期刊

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