Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance
作者： Albert Shieh , Rene F. Chun , Christina Ma , Sten Witzel , Briana Meyer
DOI: 10.1210/JC.2016-1871
关键词:
摘要: Context: Controversy persists over: 1) how best to restore low serum 25-hydroxyvitamin D (25D) levels (vitamin D2 [D2] vs vitamin D3 [D3]); 2) define status (total [protein-bound + free] free 25D); and 3) assess the bioactivity of 25D. Objective: To assess: effects on total 25D; whether change in intact PTH (iPTH) is more strongly associated with Design: Participants previously enrolled a trial were matched for age, body mass index, race/ethnicity. received 50 000 IU or twice weekly 5 weeks, followed by 5-week equilibration period. Biochemical assessment was performed at baseline 10 weeks. Setting Participants: Thirty-eight adults (19 19 D3) ≥18 years age 25D <30 ng/mL recruited from an academic ambulatory osteoporosis clinic. Outcome Measures: Serum measures 25D, (directly measured), 1...
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