Podoplanin Expression in Fibrous Histiocytomas and Cellular Neurothekeomas

作者: B Leinweber , S Kaddu

DOI: 10.1097/DAD.0B013E31819821C7

关键词:

摘要: Podoplanin, also recognized by the monoclonal antibody D2-40, is a mucin-type transmembrane glycoprotein that highly expressed in lymphatics and range of vascular nonvascular proliferations. Recently, podoplanin has been detected fibrous histiocytomas (FHs) proposed to represent potentially useful marker diagnostic evaluation this lesion. There is, however, limited data concerning expression FH its morphological mimics. Cellular neurothekeomas (CNs) are rare cutaneous neoplasms uncertain histogenesis often morphologically mimic FH. In study, we reviewed our experience with (n = 30), especially comparison CN 15). addition, immunostained selected group other mesenchymal lesions may fall within differential diagnosis for podoplanin, including dermal nerve sheath myxoma 2), dermatofibrosarcoma protuberans (N 8), plexiform fibrohistiocytic tumor 2). Podoplanin was observed significant subset FHs (26/30, 86.6%) all CNs (15/15, 100%), whereas DFSPs, myxomas, tumors were negative. To best knowledge, first report demonstrating CN. Expression represents potential pitfall use However, be value as an adjunct examination assessment problematic falling

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