Non-fibrous inorganic particles in human bronchoalveolar lavage fluids.

摘要: Bronchoalveolar lavage (BAL) is a simple and non-invasive sampling technique of the deep lung. Analytical electron microscopy was used for identification quantification non-fibrous inorganic particles recovered in BAL fluid samples from 51 subjects with various occupational exposures (silica, silicates, metals alloys, metallic oxides, precious hard metals, abrasives). Around 4750 were analysed. More than sixty different compounds identified, among which silica, kaolinite, illite, mica, Fe oxides hydroxides, appeared to be ubiquitous. Feldspar, talc, chlorite, Al oxide, Ti tungsten carbide, stainless steel, carbonaceous flyash also frequently encountered. From 1 21 identified each sample. Repeated obtained 2 did not show significant differences. Particles characteristic exposure found up years after cessation. content can reflect mixed exposures. Absolute particle concentrations measured twelve ranged between 0.1 9.9 x 10(6) particles/ml mean diameter 0.5 1.2 microns. Mineralogical analysis useful tool investigate It allows, most cases, better characterization medical questioning. may helpful identifying pathogenic particles, however it must kept mind that positive result only proof never disease. The main limitations this are difficulties severely diseased inaccuracy detecting easily soluble high rate alveolar clearance.