Novel Treatments for Drug-Resistant Tuberculosis:
作者： Jeremy M. Clain , Patricio Escalante
DOI: 10.4137/CMT.S18560
关键词:
摘要: Drug resistance has emerged as a major obstacle to global control of tuberculosis (TB). Treatment with currently available medications requires prolonged courses numerous drugs, many which are associated significant adverse effects. New drugs urgently needed meet the challenge posed by drug-resistant TB, in order relieve burden that drug placed on individual patients and health systems. Fortunately, new have been developed for treatment TB recent years. The antimycobacterial agents derived from various medication classes, work means an assortment mechanisms action, at differing phases development. This review provides survey most promising agents, promote familiarity these emerging compounds.
sagepub.com
elsevier.com
sci-hub.se 参考文章(47)
S. T. Cole, MICROBIOLOGY: Enhanced: TB-A New Target, a New Drug Science. ,vol. 307, pp. 214- 215 ,(2005) , 10.1126/SCIENCE.1108379
Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Masanori Kawasaki, Hidetsugu Tsubouchi, Hirofumi Sasaki, Yoshihiko Shimokawa, Makoto Komatsu, OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice PLOS Medicine. ,vol. 3, ,(2006) , 10.1371/JOURNAL.PMED.0030466
Norbert Heinrich, Rodney Dawson, Jeannine du Bois, Kim Narunsky, Gary Horwith, Andrew J Phipps, Carol A Nacy, Rob E Aarnoutse, Martin J Boeree, Stephen H Gillespie, Amour Venter, Sonja Henne, Andrea Rachow, Patrick PJ Phillips, Michael Hoelscher, Andreas H Diacon, Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA), Anna Maria Mekota, Norbert Heinrich, Andrea Rachow, Elmar Saathoff, Michael Hoelscher, Stephen Gillespie, Angela Colbers, Georgette Plemper van Balen, Rob Aarnoutse, Martin Boeree, Anna Bateson, Timothy McHugh, Kasha Singh, Robert Hunt, Alimuddin Zumla, Andrew Nunn, Patrick Phillips, Sunita Rehal, Rodney Dawson, Kim Narunsky, Andreas Diacon, Jeannine du Bois, Amour Venter, Sven Friedrich, Ian Sanne, Karla Mellet, Gavin Churchyard, Salome Charalambous, Peter Mwaba, Nyanda Elias, Chacha Mangu, Gabriel Rojas-Ponce, Bariki Mtafya, Leonard Maboko, Lilian Tina Minja, Mohamed Sasamalo, Klaus Reither, Levan Jugheli, Noel Sam, Gibson Kibiki, Hadija Semvua, Stellah Mpagama, Abraham Alabi, Ayola Akim Adegnika, Evans Amukoye, Alphonse Okwera, Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients Journal of Antimicrobial Chemotherapy. ,vol. 70, pp. 1558- 1566 ,(2015) , 10.1093/JAC/DKU553
J. Cohen, Approval of Novel TB Drug Celebrated—With Restraint Science. ,vol. 339, pp. 130- 130 ,(2013) , 10.1126/SCIENCE.339.6116.130
V. Makarov, G. Manina, K. Mikusova, U. Mollmann, O. Ryabova, B. Saint-Joanis, N. Dhar, M. R. Pasca, S. Buroni, A. P. Lucarelli, A. Milano, E. De Rossi, M. Belanova, A. Bobovska, P. Dianiskova, J. Kordulakova, C. Sala, E. Fullam, P. Schneider, J. D. McKinney, P. Brodin, T. Christophe, S. Waddell, P. Butcher, J. Albrethsen, I. Rosenkrands, R. Brosch, V. Nandi, S. Bharath, S. Gaonkar, R. K. Shandil, V. Balasubramanian, T. Balganesh, S. Tyagi, J. Grosset, G. Riccardi, S. T. Cole, Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis Science. ,vol. 324, pp. 801- 804 ,(2009) , 10.1126/SCIENCE.1171583
Robert S. Wallis, Wesley Jakubiec, Vikas Kumar, Gabriella Bedarida, Annette Silvia, Darcy Paige, Tong Zhu, Mark Mitton-Fry, Lynn Ladutko, Sheldon Campbell, Paul F. Miller, Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis Antimicrobial Agents and Chemotherapy. ,vol. 55, pp. 567- 574 ,(2011) , 10.1128/AAC.01179-10
Jim Werngren, Maria Wijkander, Nasrin Perskvist, V. Balasubramanian, Vasan K. Sambandamurthy, Camilla Rodrigues, Sven Hoffner, In Vitro Activity of AZD5847 against Geographically Diverse Clinical Isolates of Mycobacterium tuberculosis Antimicrobial Agents and Chemotherapy. ,vol. 58, pp. 4222- 4223 ,(2014) , 10.1128/AAC.02718-14
Maria Tarcela Gler, Vija Skripconoka, Epifanio Sanchez-Garavito, Heping Xiao, Jose L. Cabrera-Rivero, Dante E. Vargas-Vasquez, Mengqiu Gao, Mohamed Awad, Seung-Kyu Park, Tae Sun Shim, Gee Young Suh, Manfred Danilovits, Hideo Ogata, Anu Kurve, Joon Chang, Katsuhiro Suzuki, Thelma Tupasi, Won-Jung Koh, Barbara Seaworth, Lawrence J. Geiter, Charles D. Wells, Delamanid for Multidrug-Resistant Pulmonary Tuberculosis The New England Journal of Medicine. ,vol. 366, pp. 2151- 2160 ,(2012) , 10.1056/NEJMOA1112433
Emily B. Wong, Keira A. Cohen, William R. Bishai, Rising to the challenge: new therapies for tuberculosis Trends in Microbiology. ,vol. 21, pp. 493- 501 ,(2013) , 10.1016/J.TIM.2013.05.002
Debra L. Combs, USPHS Tuberculosis Short-Course Chemotherapy Trial 21: Effectiveness, Toxicity, and Acceptability Annals of Internal Medicine. ,vol. 112, pp. 397- 406 ,(1990) , 10.7326/0003-4819-76-3-112-6-397