摘要: Deficiency in the form, strength, and construction of bone tissue due to changed mineral homeostasis is named metabolic disease. The main issues that affect this are intra- extracellular levels calcium, phosphorus, magnesium, which controlled by parathyroid hormone, calcitonin, 1,25-dihydroxyvitamin D, act on bone, intestine, kidney. Usual clinical characters these pathologies electrolyte disturbances, fractures, deformity, abnormal gait, short stature demands orthopedic referral.